Anticonvulsant activity of clonazepam in experimental animals

Evaluation of Antiulcer Activity of Whole Plant Extract of Malvastrum tricuspidatum in Experimental Animals

Malvastrum tricuspidatum is recommended in Ayurveda and Folklore Medicine for the management of gastric ulcers. Therefore, the purpose of the study was to investigate the antiulcer effect of whole plant extract of Malvastrum tricuspidatum (MTE) on ethanol (EtOH)-induced, aspirin (ASP)-induced, cold-restraint-stress (CRU) and pylorus--ligation(PL)-induced gastric ulcer models in rats. Aqueo...

Anticoagulant Activity of Acenocoumarin in Experimental Animals.

Anticoagulant activity of acenocoumarin (Sintrcm) has been determined in dogs, Prothrombin values were determined according to modified Quick's method (Montigel 1962). Prothrombin index and coagulation valency were deduced from the prothrombin time. The results were compared with the reference drug ethylbiscoumacetate. Acenocoumarin was found to be 60 times more potent than ethylbiscoumacetate....

Scorpion Venom Pisoning in Experimental Animals

In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures

Background: Resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA), make it as a good candidate for designing and development of the new anticonvulsant medications. Methods: Ten DHA-based...

An experimental evaluation of anticonvulsant activity of Vitex-negundo.

Maximal electroshock seizures (MES) in albino rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract. The ethanolic leaf extract of Vitex-negundo was administered orally in graded doses (250, 500 and 1000 mg/kg p.o) in both the experimental models and the effects were compared with diphenylhydantoin in MES meth...